Nuphedragen Review And Information: Does Nuphedragen Work?

Posted By Paul on Sep 27, 2012 | 0 comments

Nuphedragen, if you care to believe the advertising material, is the key to weight loss—thanks to “breakthroughs” in modern science. Spouting impressive terms like “cocaine amphetamine regulatory transcript” (c-a-r-t) and inhibit neuropeptide-y (NPY), it’s almost as if the retailers of Nuphedragen are trying to disguise the fact that their product is pretty gosh-darn ordinary.

Because with one exception, all the ingredients in this formula have been used in fat burners since time immemorial—or darn close to it. And, as you’ll see in a moment, the clinical evidence validating their effectiveness is in pretty short supply. And the impressive sounding terms are really little more than marketing nonsense, and do nothing to improve the effectiveness of this product.

Incidentally, Nuphedragen is almost identical to another fat burner sold primarily online and on eBay — Fenphedra. Only one ingredient differentiates the two products.

You’ll find the “sales” pages for these products to be almost identical — both proclaiming the benefits of their “CART activators” and “NPY inhibitors.”

The first thing that you should know about this product is that its manufactured and retailed by a company called Devmin Research & Development, which in essence is a “re-branded” Garret Devore Labs.

Why should you care about this?

Because Garret Devore Labs holds the top position on our wall of shame, which highlights fraudulent retailers. This company has an “F” rating with the BBB, and has a long history of customer service issues. Generally, they treat their customers with contempt, are alleged to have been engaged in underhanded business practices. Generally, they are not a company with which we recommend you do business.

That said, what’s in Nuphedragen?

1. Synephrine: a chemical relative to ephedra derived from Citrus aurantium, it was once thought this compound held great promise as a fat burner. Clinical evidence, however, is inconclusive. This study on “The Safety And Efficacy of Citrus Aurantium for Weight Loss” concluded…

“An extensive search of MEDLINE, EMBASE, BIOSIS, and the Cochrane Collaboration Database identified only 1 eligible randomized placebo controlled trial, which followed 20 patients for 6 weeks, demonstrated no statistically significant benefit for weight loss, and provided limited information about the safety of the herb.”

This one (Obes Rev. 2006 Feb;7(1):79-88) had this to say…

“While some evidence is promising, we conclude that larger and more rigorous clinical trials are necessary to draw adequate conclusions regarding the safety and efficacy of C. aurantium and synephrine alkaloids for promoting weight loss.”

For the most part, however, clinical evidence has not been kind to synephrine. It’s largely useless for weight loss. Anecdotal reports suggest it may suppress your appetite somewhat, and it is a stimulant (despite assertions to the contrary), so it may give you a boost, especially when its combined with caffeine, as it is in this formula.

2. Phenylethylamine (PEA): an amphetamine-related chemical commonly found in chocolate, and once thought to be responsible for the famous “chocolate high.” You’ll find phenylethylamine in many fat burners these days, but for the most part it’s a useless addition to any formula.

First of all, there’s no published evidence indicating PEA offers benefits (of any sort) to dieters.

Secondly, the vast majority of any phenylethylamine you consume orally is quickly metabolized by an enzyme called monamine oxidase.

This prevents all but the tiniest amounts from actually reaching the bloodstream.

The only fat burners in which phenylethylamine may have any impact are those that also contain natural monamine oxidase inhibitors (MAOI) to prevent the metabolism of this ingredient. Unfortunately, there aren’t any in this formula.

Gaspari’s Cytolean (reviewed here) was probably the best of the bunch, as its formula contained 5 natural MAOIs. Nutrex’s Lipo 6 X (reviewed here) contains a single MAOI in its formula.

But as far as the PEA content in Nuphedragen? It’s a bust.

3. Chocamine™: A proprietary extract derived from the cocoa plant. It contains methylxanthines (caffeine and caffeine-like compounds), biogenic amines (defined as “neurotransmitter-related” compounds), as well as amino acids, phyonutrients, minerals, and so on.

Although caffeine’s ability to work as a fat burner is well established, the effectiveness of other elements of this compound are less so — especially at this low dose. And I didn’t find any clinical studies listed in the PubMed database validating Chocamine™’s positive effects on weight loss (or anything else for that matter).

4. DiCaffeine Malate: The benefits of caffeine for weight loss are well established (see Am J Clin Nutr. 1989 Jan;49(1):44-50, Am J Clin Nutr. 1980 May;33(5):989-97), and therefore it’s an important addition to any fat burner.

Why use this version of caffeine as opposed to the “regular stuff”? This special “caffeine-bonded-with-malic-acid” is supposed to be more effective, more easily assimilated, and easier on the stomach than “regular” caffeine.

However, there is no clinical evidence at this time indicating it offers any fat burning benefits above and beyond those already demonstrated by caffeine.

What’s the bottom line on Nuphedragen?

Short of the caffeine, none of the ingredients in this formula have much clinical data validating their usefulness for weight loss.

And of course, there have been no clinical studies performed on the Nuphedragen formula itself.

Plus, its outrageously priced at $60 a bottle (the price is discounted if you make a volume purchase). But check this out…

At a credible online retailer like BodyBuilding.com you can create a similar stack (one cap of each twice a day would likely duplicate the results of Nuphedragen) for much less money…

• AllMax caffeine (100 200mg tabs) $4.00
• Synephrine (180 10mg capsules) $12.00
• Chocamine (90 100 mg tabs) $9.00

At $25, this is less than half the price, and there’s more than 6 weeks worth of supply here. See what I mean? Nuphedragen is expensive… there’s nothing here to justify such a cost.

Bottom line?

There are simply much better, lower-priced products available on the market for you to bother with Nuphedragen. And Garret Devore labs does not deserve your business.