Glycocyamine
An intermediate in creatine synthesis. It’s included in certain creatine transport supplements as it represents an additional pathway for increasing creatine storage in muscle tissue. It also has hypoglycemic effects, and may be able to enhance creatine uptake in muscle without a sugar-mediated insulin spike.
Glycocyamine is a questionable addition as it can also increase homocysteine (a risk factor for cardiovascular disease), compete with creatine transporters and cause seizures in larger amounts. While probably not hazardous in the amounts used in most supplements, there is no human data to justify its use.
See Elissa’s blog post: “Ingredient Watch: Glycocyamine” for more information. David Tolson also has an informative summary: “Glycocyamine and Health.”
