-(-)3,4-Divanillyltetrahydrofuran
A bioactive compound in “Stinging Nettle” (Urtica dioica) used in certain bodybuilding/testosterone-boosting supplements. In-vitro research has shown it can bind tightly to sex hormone binding globulin (SHBG), so theoretically, it has the potential to increase bioavailable (free) testosterone. There are no human—or even animal—studies, however, so at this point, the ability of oral -(-)3, 4-Divanillyltetrahydrofuran to enhance free testosterone is purely speculative.